Article
Metabolism of polycyclic aromatic hydrocarbons to mutagenic species by rat and porcine ovarian granulosa cells: detection by cocultivation with V79 Chinese hamster cells.
Reproductive toxicology (Elmsford, N.Y.) - 1 Jan 2000
Becedas L, Romert L, Toft E, Jenssen D, DePierre J W, Ahlberg M B
Abstract excerpt
The capacity of ovarian granulosa cells from rat and pig to release reactive metabolites produced from polycyclic aromatic hydrocarbons with the ability to cause mutations in neighbouring cells has been studied. For this purpose we have used cocultivation with V79 Chinese hamster cells as a detec...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Animals
- Biotransformation
- Cells, Cultured
- Cricetinae
- Cricetulus
- Dihydroxydihydrobenzopyrenes
- Female
- Granulosa Cells
- Hypoxanthine Phosphoribosyltransferase
- Kinetics
- Mutagens
- Mutation
- Oocytes
- Ovary
- Polycyclic Compounds
- Progesterone
- Rats