High-density lipoproteins decrease both DNA binding and mutagenicity of r-7,t-8-dihydroxy-t-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in V79 Chinese hamster cells.

doi:10.1016/0027-5107(86)90115-6

Article

High-density lipoproteins decrease both DNA binding and mutagenicity of r-7,t-8-dihydroxy-t-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in V79 Chinese hamster cells.

Mutation research - 1 Jan 2000

Yoo J S, Norman J O, Joe C O, Busbee D L

Abstract excerpt

The effects of separate lipoproteins or of serum with high or low lipoprotein concentrations on formation of lipophilic carcinogen adducts with DNA and on mutagenicity of the carcinogen was investigated using V79 Chinese hamster lung cells. Binding of r-7,t-8-dihydroxy-t-9,10-epoxy-7,8,9,10-tetra...

Topics

7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Animals
Benzopyrenes
Cell Line
Cricetinae
Cricetulus
Culture Media
DNA
DNA Adducts
Drug Synergism
Lipoproteins, HDL
Lipoproteins, LDL
Lung
Mutation

High-density lipoproteins decrease both DNA binding and mutagenicity of r-7,t-8-dihydroxy-t-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in V79 Chinese hamster cells.

Abstract excerpt

Topics

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