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Selective increase in cellular Aβ42 is related to apoptosis but not necrosis

1 Jan 2000

Abstract excerpt

Amyloid beta protein ending at 42 (A beta 42) plays an important role in the pathology of Alzheimer's disease (AD). Here we show an increase in cellular A beta 42 in damaged neurons, with both ELISA and immunocytochemistry. The cellular A beta 42 increase was caused by 3-day treatments with H2O2, etoposide or melphalan, all of which induce genotoxic apoptosis, but not by treatment with sodium azide, which causes...

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PMID: 10683851
DOI: 10.1097/00001756-200001170-00033

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