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Article

The significance of Exo1 K589E polymorphism on cancer susceptibility: evidence based on a meta-analysis.

PloS one - 1 Jan 2014

Duan Fujiao, Song Chunhua, Dai Liping, Cui Shuli, Zhang Xiaoqin, Zhao Xia

Abstract excerpt

The exonuclease1 (Exo1) gene is a key component of mismatch repair (MMR) by resecting the damaged strand, which is the only exonuclease involved in the human MMR system. The gene product is a member of the RAD2 nuclease family and functions in DNA replication, repair and recombination. However, whether Exo1 is required to activate MMR-dependent DNA damage response (DDR) remains unknown, the conclusions of the...

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Identifiers

PMID: 24810280
DOI: 10.1371/journal.pone.0096764
PMCID: PMC4014567

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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