Article
FLT3 inhibition upregulates HDAC8 via FOXO to inactivate p53 and promote maintenance of FLT3-ITD+ acute myeloid leukemia.
Blood - 23 Apr 2020
Long Jun, Jia Ming-Yuan, Fang Wei-Yue, Chen Xin-Jie, Mu Li-Li, Wang Zhong-Yu, Shen Yan, Xiang Ru-Fang, Wang Li-Ning, Wang Ling, Jiang Chuan-He, Jiang Jie-Ling, Zhang Wen-Jun, Sun Yi-Dan, Chang Li, Gao Wen-Hui, Wang Ying, Li Jun-Min, Hong Deng-Li, Liang Ai-Bin, Hu Jiong
Abstract excerpt
Internal tandem duplication (ITD) mutations within the FMS-like receptor tyrosine kinase-3 (FLT3) can be found in up to 25% to 30% of acute myeloid leukemia (AML) patients and confer a poor prognosis. Although FLT3 tyrosine kinase inhibitors (TKIs) have shown clinical responses, they cannot eliminate primitive FLT3-ITD+ AML cells, which are potential sources of relapse. Therefore, elucidating the mechanisms...
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