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The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia

31 Aug 2021

Abstract excerpt

Ubiquitin-specific peptidase 15 (USP15) is a deubiquitinating enzyme implicated in critical cellular and oncogenic processes. We report that USP15 mRNA and protein are overexpressed in human acute myeloid leukemia (AML) as compared to normal hematopoietic progenitor cells. This high expression of USP15 in AML correlates with KEAP1 protein and suppression of NRF2. Knockdown or deletion of USP15 in human and mouse...

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PMID: 34465865
DOI: 10.1038/s41375-021-01394-z

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