Article
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
Nature genetics - 1 Sept 2018
Nielsen Jonas B, Thorolfsdottir Rosa B, Fritsche Lars G, Zhou Wei, Skov Morten W, Graham Sarah E, Herron Todd J, McCarthy Shane, Schmidt Ellen M, Sveinbjornsson Gardar, Surakka Ida, Mathis Michael R, Yamazaki Masatoshi, Crawford Ryan D, Gabrielsen Maiken E, Skogholt Anne Heidi, Holmen Oddgeir L, Lin Maoxuan, Wolford Brooke N, Dey Rounak, Dalen Håvard, Sulem Patrick, Chung Jonathan H, Backman Joshua D, Arnar David O, Thorsteinsdottir Unnur, Baras Aris, O'Dushlaine Colm, Holst Anders G, Wen Xiaoquan, Hornsby Whitney, Dewey Frederick E, Boehnke Michael, Kheterpal Sachin, Mukherjee Bhramar, Lee Seunggeun, Kang Hyun M, Holm Hilma, Kitzman Jacob, Shavit Jordan A, Jalife José, Brummett Chad M, Teslovich Tanya M, Carey David J, Gudbjartsson Daniel F, Stefansson Kari, Abecasis Gonçalo R, Hveem Kristian, Willer Cristen J
Abstract excerpt
To identify genetic variation underlying atrial fibrillation, the most common cardiac arrhythmia, we performed a genome-wide association study of >1,000,000 people, including 60,620 atrial fibrillation cases and 970,216 controls. We identified 142 independent risk variants at 111 loci and prioritized 151 functional candidate genes likely to be involved in atrial fibrillation. Many of the identified risk variants...
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