Article
Whole Exome Sequencing in Atrial Fibrillation.
PLoS genetics - 1 Sept 2016
Lubitz Steven A, Brody Jennifer A, Bihlmeyer Nathan A, Roselli Carolina, Weng Lu-Chen, Christophersen Ingrid E, Alonso Alvaro, Boerwinkle Eric, Gibbs Richard A, Bis Joshua C, Cupples L Adrienne, Mohler Peter J, Nickerson Deborah A, Muzny Donna, Perez Marco V, Psaty Bruce M, Soliman Elsayed Z, Sotoodehnia Nona, Lunetta Kathryn L, Benjamin Emelia J, Heckbert Susan R, Arking Dan E, Ellinor Patrick T, Lin Honghuang
Abstract excerpt
Atrial fibrillation (AF) is a morbid and heritable arrhythmia. Over 35 genes have been reported to underlie AF, most of which were described in small candidate gene association studies. Replication remains lacking for most, and therefore the contribution of coding variation to AF susceptibility remains poorly understood. We examined whole exome sequencing data in a large community-based sample of 1,734...
Topics
- Aged
- Atrial Fibrillation
- Exome
- Female
- Gene Frequency
- Genetic Association Studies
- Genetic Predisposition to Disease
- High-Throughput Nucleotide Sequencing