Article
Genetic Control of Left Atrial Gene Expression Yields Insights into the Genetic Susceptibility for Atrial Fibrillation.
Circulation. Genomic and precision medicine - 1 Mar 2018
Hsu Jeffrey, Gore-Panter Shamone, Tchou Gregory, Castel Laurie, Lovano Beth, Moravec Christine S, Pettersson Gosta B, Roselli Eric E, Gillinov A Marc, McCurry Kenneth R, Smedira Nicholas G, Barnard John, Van Wagoner David R, Chung Mina K, Smith Jonathan D
Abstract excerpt
BACKGROUND: Genome-wide association studies have identified 23 loci for atrial fibrillation (AF), but the mechanisms responsible for these associations, as well as the causal genes and genetic variants, remain undefined. METHODS: To identify the effect of common genetic variants on gene expression that might explain the mechanisms linking genome-wide association loci with AF risk, we performed RNA sequencing of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.