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Article

Sex differences in genotype frequency and the risk of polycythemia associated with rs13419896 and rs2790859 among Tibetan highlanders living in Tsarang, Mustang, Nepal.

Journal of physiological anthropology - 15 Oct 2024

Arima Hiroaki, Nishimura Takayuki, Koirala Sweta, Nakano Masayuki, Ito Hiromu, Ichikawa Tomo, Pandey Kishor, Pandey Basu Dev, Yamamoto Taro

Abstract excerpt

BACKGROUND: Tibetan highlanders have adapted to hypoxic environments through genetic mechanisms that avoid hemoglobin concentration increases and prevent polycythemia. Recently, sex differences in hemoglobin dynamics with age have been reported among Tibetan highlanders living in Tsarang. Additionally, concerns have been raised that dietary changes associated with modernization may increase the risk of...

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PMID: 39407294
DOI: 10.1186/s40101-024-00372-5
PMCID: PMC11477017

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