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Article

Genetic variants in EPAS1 contribute to adaptation to high-altitude hypoxia in Sherpas.

PloS one - 1 Jan 2012

Hanaoka Masayuki, Droma Yunden, Basnyat Buddha, Ito Michiko, Kobayashi Nobumitsu, Katsuyama Yoshihiko, Kubo Keishi, Ota Masao

Abstract excerpt

Sherpas comprise a population of Tibetan ancestry in the Himalayan region that is renowned for its mountaineering prowess. The very small amount of available genetic information for Sherpas is insufficient to explain their physiological ability to adapt to high-altitude hypoxia. Recent genetic evidence has indicated that natural selection on the endothelial PAS domain protein 1 (EPAS1) gene was occurred in the...

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Source

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Identifiers

PMID: 23227185
DOI: 10.1371/journal.pone.0050566
PMCID: PMC3515610

Genes

EPAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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