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Mosaicism, aging and cancer

24 Jan 2019

Abstract excerpt

PURPOSE OF REVIEW: Genetic mosaicism is the presence of a somatic mutation in a subset of cells that differs from the inherited germline genome. Detectable genetic mosaicism is attractive as a potential early biomarker for cancer risk because of its established relationship with aging, introduction of potentially deleterious mutations, and clonal selection and expansion of mutated cells. The aim of this review is...

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PMID: 30585859
DOI: 10.1097/cco.0000000000000500

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