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Isotretinoin promotes elimination of translation-competent HIV latent reservoirs in CD4T cells

14 Oct 2024

Abstract excerpt

Development of novel therapeutic strategies that reactivate latent HIV and sensitize reactivated cells to apoptosis is crucial towards elimination of the latent viral reservoir. Among the clinically relevant latency reversing agents (LRA) under investigation, the γc-cytokine IL-15 and the superagonist N-803 have been shown to reactivate latent HIV ex vivo and in vivo. However, their clinical benefit can be...

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PMID: 39401241
DOI: 10.1371/journal.ppat.1012601

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