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Latency reversal agents affect differently the latent reservoir present in distinct CD4+ T subpopulations

19 Aug 2019

Abstract excerpt

Latency reversal agents (LRAs) have proven to induce HIV-1 transcription in vivo but are ineffective at decreasing the size of the latent reservoir in antiretroviral treated patients. The capacity of the LRAs to perturb the viral reservoir present in distinct subpopulations of cells is currently unknown. Here, using a new RNA FISH/flow ex vivo viral reactivation assay, we performed a comprehensive assessment of...

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PMID: 31425551
DOI: 10.1371/journal.ppat.1007991

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