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The Mutational and Transcriptional Landscapes of Hepatocarcinogenesis in a Rat Model

15 Oct 2020

Abstract excerpt

Hepatocellular carcinoma (HCC) initiation is characterized by stepwise accumulation of molecular alterations, during which the early events are largely unknown. Here, we presented a comprehensive genomic and transcriptomic landscape at stages of hepatitis, cirrhosis, and HCC by using a diethylnitrosamine-induced rat HCC model. We observed the early occurrence of gene instability and aberrant cancer associated...

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PMID: 33163943
DOI: 10.1016/j.isci.2020.101690

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