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Article

Chaperone-mediated autophagy modulates Snail protein stability: implications for breast cancer metastasis

11 Oct 2024

Abstract excerpt

Breast cancer remains a significant health concern, with triple-negative breast cancer (TNBC) being an aggressive subtype with poor prognosis. Epithelial-mesenchymal transition (EMT) is important in early-stage tumor to invasive malignancy progression. Snail, a central EMT component, is tightly regulated and may be subjected to proteasomal degradation. We report a novel proteasomal independent pathway involving...

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PMID: 39390584
DOI: 10.1186/s12943-024-02138-0

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