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The role of Runx2 in facilitating autophagy in metastatic breast cancer cells

27 Mar 2017

Abstract excerpt

Breast cancer metastases cause significant patient mortality. During metastases, cancer cells use autophagy, a catabolic process to recycle nutrients via lysosomal degradation, to overcome nutritional stress for their survival. The Runt-related transcription factor, Runx2, promotes cell survival under metabolic stress, and regulates breast cancer progression and bone metastases. Here, we identify that Runx2...

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PMID: 28345763
DOI: 10.1002/jcp.25916

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