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Article

EMT impairs breast carcinoma cell susceptibility to CTL-mediated lysis through autophagy induction.

Autophagy - 1 Jul 2013

Akalay Intissar, Janji Bassam, Hasmim Meriem, Noman Muhammad Zaeem, Thiery Jean Paul, Mami-Chouaib Fathia, Chouaib Salem

Abstract excerpt

Epithelial to mesenchymal transition (EMT) has become one of the most exciting fields in cancer biology. While its role in cancer cell invasion, metastasis and drug resistance is well established, the molecular basis of EMT-induced immune escape remains unknown. We recently reported that EMT coordinately regulates target cell recognition and sensitivity to specific lysis. In addition to the well-characterized...

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Identifiers

PMID: 23635487
DOI: 10.4161/auto.24728
PMCID: PMC3722321

Genes

BECN1

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