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Article

LC3C mediates selective autophagy of the MET RTK, inhibiting cancer cell invasion

16 Feb 2020

Abstract excerpt

Macroautophagy/autophagy is an evolutionarily conserved degradative process with a central role in maintaining cellular homeostasis under conditions of stress, and recent evidence suggests this may occur in part through direct modification of cell signaling. The MET/HGF receptor tyrosine kinase (RTK) signaling axis is an important mediator of cell motility and invasion in normal cell functions and in cancer. We...

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PMID: 32065021
DOI: 10.1080/15548627.2020.1728099

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