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Resistomycin attenuates triple-negative breast cancer progression by inhibiting E3 ligase Pellino-1 and inducing SNAIL/SLUG degradation

29 Jul 2020

Abstract excerpt

The epithelial-to-mesenchymal transition (EMT) is a positive modulator of triple-negative breast cancer (TNBC) progression. 1 Several EMT-inducing transcriptional factors (EMT-TFs) drive EMT process and enhance TNBC progression. 2 Promoting the degradation of EMT-TFs to inhibit EMT and malignant actions holds therapeutic potential for TNBC patients.

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PMID: 32728028
DOI: 10.1038/s41392-020-00255-y

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