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Article

A link between LRRK2, autophagy and NAADP-mediated endolysosomal calcium signalling.

Biochemical Society transactions - 1 Oct 2012

Gómez-Suaga Patricia, Churchill Grant C, Patel Sandip, Hilfiker Sabine

Abstract excerpt

Mutations in LRRK2 (leucine-rich repeat kinase 2) represent a significant component of both sporadic and familial PD (Parkinson's disease). Pathogenic mutations cluster in the enzymatic domains of LRRK2, and kinase activity seems to correlate with cytotoxicity, suggesting the possibility of kinase-based therapeutic strategies for LRRK2-associated PD. Apart from cytotoxicity, changes in autophagy have consistently...

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Source

Identifiers

PMID: 22988879
DOI: 10.1042/BST20120138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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