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Article

Functional characterization of single nucleotide polymorphic variants of DNA repair enzyme NEIL1 in South Asian populations.

DNA repair - 1 Jul 2024

Zuckerman Jamie T, Jackson Asia Sage, Minko Irina G, Kant Melis, Jaruga Pawel, Stone Michael P, Dizdaroglu Miral, McCullough Amanda K, Lloyd R Stephen

Abstract excerpt

The base excision repair (BER) pathway is a precise and versatile mechanism of DNA repair that is initiated by DNA glycosylases. Endonuclease VIII-like 1 (NEIL1) is a bifunctional glycosylase/abasic site (AP) lyase that excises a damaged base and subsequently cleaves the phosphodiester backbone. NEIL1 is able to recognize and hydrolyze a broad range of oxidatively-induced base lesions and substituted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38795603
DOI: 10.1016/j.dnarep.2024.103695
PMCID: PMC11218669

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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