Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High risk of benzo[α]pyrene-induced lung cancer in E160D FEN1 mutant mice.

Mutation research - 1 Mar 2012

Wu Zhenxing, Lin Yuanji, Xu Hong, Dai Huifang, Zhou Mian, Tsao Sharlene, Zheng Li, Shen Binghui

Abstract excerpt

Flap endonuclease 1 (FEN1), a member of the Rad2 nuclease family, possesses 5' flap endonuclease (FEN), 5' exonuclease (EXO), and gap-endonuclease (GEN) activities. The multiple, structure-specific nuclease activities of FEN1 allow it to process different intermediate DNA structures during DNA replication and repair. We previously identified a group of FEN1 mutations and single nucleotide polymorphisms that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Chromosome Aberrations
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Flap Endonucleases

Share to Lung Neoplasms

Share to Mice, Mutant Strains

Source

Open in PubMed Open full text

Identifiers

PMID: 22155171
DOI: 10.1016/j.mrfmmm.2011.11.009
PMCID: PMC3268909

Genes

FEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High risk of benzo[α]pyrene-induced lung cancer in E160D FEN1 mutant mice.PMID 22155171Read ↗

Chemical-induced cancer incidence and underlying mechanisms in Fen1 mutant mice.Semantic proximity Read ↗

Fen1 mutations result in autoimmunity, chronic inflammation and cancers.Semantic proximity Read ↗

Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants.Semantic proximity Read ↗

The FEN1 L209P mutation interferes with long-patch base excision repair and induces cellular transformation.Semantic proximity Read ↗

The Distinct Roles of NEIL1 and XPA in Limiting Aflatoxin B1-Induced Mutagenesis in Mice.Semantic proximity Read ↗

Adenomatous polyposis coli interacts with flap endonuclease 1 to block its nuclear entry and function.Semantic proximity Read ↗

Functional FEN1 polymorphisms are associated with DNA damage levels and lung cancer risk.Semantic proximity Read ↗

Functional FEN1 genetic variants contribute to risk of hepatocellular carcinoma, esophageal cancer, gastric cancer and colorectal cancer.Semantic proximity Read ↗

Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in <i> Exo1 <sup>D173A</sup> </i> miceSemantic proximity Read ↗

The DNA-protein interaction modes of FEN-1 with gap substrates and their implication in preventing duplication mutations.Semantic proximity Read ↗

Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression.Semantic proximity Read ↗

Proliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stage.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.