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DNA demethylation triggers cell free DNA release in colorectal cancer cells

9 Oct 2024

Abstract excerpt

BACKGROUND: Liquid biopsy based on cell-free DNA (cfDNA) analysis holds significant promise as a minimally invasive approach for the diagnosis, genotyping, and monitoring of solid malignancies. Human tumors release cfDNA in the bloodstream through a combination of events, including cell death, active and passive release. However, the precise mechanisms leading to cfDNA shedding remain to be characterized....

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PMID: 39385243
DOI: 10.1186/s13073-024-01386-5

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