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Tissue architecture and immune niches govern ctDNA release in colorectal cancer

2026-03-25

Abstract excerpt

<title>Abstract</title> <p>Circulating tumor DNA (ctDNA) is central to liquid biopsy-based cancer detection, yet the biological basis of its highly variable release into the bloodstream remains poorly understood. To define the tissue-level determinants of ctDNA shedding in colorectal cancer (CRC), we integrated tumor-informed plasma sequencing with detailed histopathology, immunophenotyping, spatial transcriptomi...

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Literature Corpus work: 3700c661-03c6-5f04-a3b0-42c23d54beed
DOI: 10.21203/rs.3.rs-8927102/v1

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