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Circulating cell‐free DNA release in vitro: kinetics, size profiling, and cancer‐related gene methylation

7 Jan 2019

Abstract excerpt

Abstract Circulating cell‐free DNA (ccfDNA) is a biological entity of great interest due to its potential as liquid biopsy biomaterial carrying clinically valuable information. To better understand its nature, we studied ccfDNA in vitro in two human cancer cell lines MCF‐7 and HeLa. Normalized indexes of ccfDNA per cell population decreased over time of culture but were significantly elevated after exposure to IC...

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PMID: 30618174
DOI: 10.1002/jcp.28097

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