Article

Global Hypomethylation in Cell-free DNA Enables Non-invasive Colorectal Cancer Screening: Results from a Retrospective Validation Study

2026-02-25

Abstract excerpt

<title>Abstract</title> <p>Background Global DNA hypomethylation is a fundamental epigenetic hallmark of colorectal cancer, yet it remains difficult to measure in circulating cell-free DNA using existing technologies that focus on a limited number of genomic loci. As a result, global hypomethylation has not been effectively translated into non-invasive diagnostics. We evaluated a label-free electrical impedance...

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Literature Corpus work: 442fb02a-7d88-5589-baf8-b100110a2ab8
DOI: 10.21203/rs.3.rs-8682249/v1

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