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Epigenetic analysis of cell-free DNA by fragmentomic profiling

26 Oct 2022

Abstract excerpt

Cell-free DNA (cfDNA) fragmentation patterns contain important molecular information linked to tissues of origin. We explored the possibility of using fragmentation patterns to predict cytosine-phosphate-guanine (CpG) methylation of cfDNA, obviating the use of bisulfite treatment and associated risks of DNA degradation. This study investigated the cfDNA cleavage profile surrounding a CpG (i.e., within an...

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PMID: 36288287
DOI: 10.1073/pnas.2209852119

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