Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer.

doi:10.1136/gutjnl-2016-313372

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Article

Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer.

Gut - 1 Nov 2018

Barault Ludovic, Amatu Alessio, Siravegna Giulia, Ponzetti Agostino, Moran Sebastian, Cassingena Andrea, Mussolin Benedetta, Falcomatà Chiara, Binder Alexandra M, Cristiano Carmen, Oddo Daniele, Guarrera Simonetta, Cancelliere Carlotta, Bustreo Sara, Bencardino Katia, Maden Sean, Vanzati Alice, Zavattari Patrizia, Matullo Giuseppe, Truini Mauro, Grady William M, Racca Patrizia, Michels Karin B, Siena Salvatore, Esteller Manel, Bardelli Alberto, Sartore-Bianchi Andrea, Di Nicolantonio Federica

Abstract excerpt

OBJECTIVE: Mutations in cell-free circulating DNA (cfDNA) have been studied for tracking disease relapse in colorectal cancer (CRC). This approach requires personalised assay design due to the lack of universally mutated genes. In contrast, early methylation alterations are restricted to defined genomic loci allowing comprehensive assay design for population studies. Our objective was to identify cancer-specific...

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PMID: 28982739
DOI: 10.1136/gutjnl-2016-313372
PMCID: PMC5897187

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EYA4
GRIA4
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MSC

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