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[Effect analysis of trimethylamine N-oxide and its precursors on susceptibility to pancreatic diseases].

Zhonghua wei zhong bing ji jiu yi xue - 1 Sept 2024

Liu Jie, Luo Xinyu, Pei Boliang, Ge Peng, Ma Shurong, Luo Yalan, Chen Hailong

Abstract excerpt

OBJECTIVE: To investigate the causal relationship between trimethylamine N-oxide (TMAO) and its precursors (betaine, carnitine, and choline) and pancreatic diseases based on the Mendelian randomization (MR) method. METHODS: Genome-wide association study data of TMAO, betaine, carnitine, choline, acute pancreatitis (AP), chronic pancreatitis (CP), pancreatic cancer (PC), and circulating immune cell characteristics...

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PMID: 39380516
DOI: 10.3760/cma.j.cn121430-20231213-01083

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