Article

Integrated Clinicogenomic Risk Modeling for Metachronous Second Primary Cancers

2026-06-22

Abstract excerpt

Improvements in cancer survival have increased the burden of subsequent primary malignancies. We developed and validated a programmatic classifier of multiple primary cancers (MPC) to derive second cancer phenotypes at scale. Among 81,175 cancer patients, we identified 56 first-second cancer pairs, 22 of which exceeded SEER primary cancer incidence rates. Even after accounting for various known risk factors, subst...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 940255da-4475-535f-b964-4b3362d9de71
DOI: 10.64898/2026.06.12.26355388

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated Clinicogenomic Risk Modeling for Metachronous Second Primary CancersDOI 10.64898/2026.06.12.26355388Read

Triple Primary Cancers: An Analysis of Genetic and Environmental Factors.Semantic proximity Read

Risk of Second Primary Cancers After a Diagnosis of First Primary Cancer: A Pan-Cancer Analysis and Mendelian Randomization StudySemantic proximity Read

Risk of second primary cancers after a diagnosis of first primary cancer: A pan-cancer analysis and Mendelian randomization studySemantic proximity Read

Assessment of Genetic Susceptibility to Multiple Primary Cancers through Whole-Exome Sequencing in Two Large Multi-Ancestry StudiesSemantic proximity Read

Assessment of genetic susceptibility to multiple primary cancers through whole-exome sequencing in two large multi-ancestry studies.Semantic proximity Read

Identifying and screening patients at risk of second cancers.Semantic proximity Read

Risk of Different Cancers Among First-degree Relatives of Pancreatic Cancer Patients: Influence of Probands' Susceptibility Gene Mutation Status.Semantic proximity Read

Comparative Analysis of Predictive Models for Individual Cancer Risk: Approaches and ApplicationsSemantic proximity Read

The epidemiology of second primary cancers.Semantic proximity Read

Aetiology, genetics and prevention of secondary neoplasms in adult cancer survivors.Semantic proximity Read

Solid tumor second primary neoplasms: who is at risk, what can we do?Semantic proximity Read

Expansion of Cancer Risk Profile for BRCA1 and BRCA2 Pathogenic Variants.Semantic proximity Read