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Article

Patterns of Human Leukocyte Antigen Class I and Class II Associations and Cancer.

Cancer research - 15 Feb 2021

Liu Zhiwei, Derkach Andriy, Yu Kelly J, Yeager Meredith, Chang Yu-Sun, Chen Chien-Jen, Gyllensten Ulf, Lan Qing, Lee Mei-Hsuan, McKay James D, Rothman Nathaniel, Yang Hwai-I, Hildesheim Allan, Pfeiffer Ruth M

Abstract excerpt

Human leukocyte antigen (HLA) gene variation is associated with risk of cancers, particularly those with infectious etiology or hematopoietic origin, given its role in immune presentation. Previous studies focused primarily on HLA allele/haplotype-specific associations. To answer whether associations are driven by HLA class I (essential for T-cell cytotoxicity) or class II (important for T-cell helper responses)...

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Identifiers

PMID: 33272927
DOI: 10.1158/0008-5472.CAN-20-2292
PMCID: PMC9986718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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