Article

Association between cancer risk and HLA genotype can be explained by anti-tumor immunity

2021-03-10

Abstract excerpt

<title>Abstract</title> <p>Over recent decades, efforts to explain the heritability of developing cancer have focused on identifying high-risk genes and common genetic variants. However, no studies considered genetic factors regulating tumor-specific immune responses. By developing a novel human leukocyte antigen (HLA) score, determined by autologous HLA allele-binding epitopes of tumor-specific antigens, we show...

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Literature Corpus work: 6ea67473-4fa0-5040-b163-ec7fde4b8f29
DOI: 10.21203/rs.3.rs-244862/v1

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