Advances on the role of lung macrophages in the pathogenesis of chronic obstructive pulmonary disease in the Era of Single-Cell Genomics

Abstract excerpt

Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous respiratory disorder characterized by persistent airflow limitation. The diverse pathogenic mechanisms underlying COPD progression remain incompletely understood. Macrophages, serving as the most representative immune cells in the respiratory tract, constitute the first line of innate immune defense and maintain pulmonary immunological homeostasis....

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