Article
Errors in translation cause selective neurodegeneration.
ACS chemical biology - 24 Oct 2006
Rochet Jean-Christophe
Abstract excerpt
The 3D structure of a protein is determined by the unique sequence of amino acid residues comprising the polypeptide chain. Sequence changes can cause protein misfolding, a potentially toxic phenomenon implicated in various neurodegenerative disorders. In a recent paper, translational misincorpor...
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