Article
Molecular misreading. A new type of transcript mutation in gerontology.
Annals of the New York Academy of Sciences - 1 Jun 2000
van Leeuwen F W, Fischer D F, Benne R, Hol E M
Abstract excerpt
Molecular misreading is a novel process that causes mutations in neuronal transcripts. It is defined as the inaccurate conversion of genomic information from DNA into nonsense transcripts and the subsequent translation into mutant proteins. As a result of dinucleotide deletions (delta GA, delta GU, delta CU) in and around GAGAG motifs in mRNA the reading frame shifts to the +1 frame, and subsequently the...
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