Article
Effects and interaction of single nucleotide polymorphisms at the pharmacokinetic/pharmacodynamic site: insights from the Rotterdam study into metformin clinical response and dose titration.
The pharmacogenomics journal - 7 Oct 2024
Mohammadi Jouabadi Soroush, Peymani Payam, Nekouei Shahraki Mitra, van Rooij Jeroen G J, Broer Linda, Roks Anton J M, Stricker Bruno H, Ahmadizar Fariba
Abstract excerpt
Our study investigated the impact of genetic variations on metformin glycemic response in a cohort from the Rotterdam Study, comprising 14,926 individuals followed for up to 27 years. Among 1285 metformin users of European ancestry, using linear mixed models, we analyzed the association of single nucleotide polymorphisms (SNPs) and a Polygenic Risk Score (PRS) with glycemic response, measured by changes in...
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