Article
Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin.
Clinical pharmacology and therapeutics - 1 Sept 2014
Goswami S, Yee S W, Stocker S, Mosley J D, Kubo M, Castro R, Mefford J A, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson M D, Hedderson M M, Davis R L, Roden D M, Giacomini K M, Savic R M
Abstract excerpt
One-third of type 2 diabetes patients do not respond to metformin. Genetic variants in metformin transporters have been extensively studied as a likely contributor to this high failure rate. Here, we investigate, for the first time, the effect of genetic variants in transcription factors on metformin pharmacokinetics (PK) and response. Overall, 546 patients and healthy volunteers contributed their genome-wide,...
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