BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomas.

doi:10.7554/eLife.91313

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Article

BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomas.

eLife - 7 Oct 2024

Huchede Paul, Meyer Swann, Berthelot Clément, Hamadou Maud, Bertrand-Chapel Adrien, Rakotomalala Andria, Manceau Line, Tomine Julia, Lespinasse Nicolas, Lewandowski Paul, Cordier-Bussat Martine, Broutier Laura, Dutour Aurélie, Rochet Isabelle, Blay Jean-Yves, Degletagne Cyril, Attignon Valéry, Montero-Carcaboso Angel, Le Grand Marion, Pasquier Eddy, Vasiljevic Alexandre, Gilardi-Hebenstreit Pascale, Meignan Samuel, Leblond Pierre, Ribes Vanessa, Cosset Erika, Castets Marie

Abstract excerpt

Pediatric diffuse midline gliomas (pDMG) are an aggressive type of childhood cancer with a fatal outcome. Their major epigenetic determinism has become clear, notably with the identification of K27M mutations in histone H3. However, the synergistic oncogenic mechanisms that induce and maintain tumor cell phenotype have yet to be deciphered. In 20 to 30% of cases, these tumors have an altered BMP signaling pathway...

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PMID: 39373720
DOI: 10.7554/eLife.91313
PMCID: PMC11458179

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