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Molecular Analysis of PIK3CA in Metastatic Hormone Receptor-Positive Breast Cancer in Chile: Clinical and Pathological Insights.

International journal of molecular sciences - 14 Nov 2024

Araya Carla, Mino Bárbara, Le Cerf Patricio, Gaete Fancy, Armisen Ricardo, Carvajal-Hausdorf Daniel E

Abstract excerpt

Breast cancer is the most common cancer among women and a leading cause of cancer-related deaths. PIK3CA gene mutations, which are often present in advanced HR+ breast cancer, can be targeted by alpelisib. However, data on PIK3CA mutations in Chile are limited. Here, we aim to assess the mutational status of PIK3CA in metastatic breast cancer tissues from Chilean patients and describe their clinicopathological...

Topics

Humans
Class I Phosphatidylinositol 3-Kinases
Female
Breast Neoplasms
Middle Aged
Chile
Mutation
Aged
Adult
Receptor, ErbB-2
Neoplasm Metastasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Estrogen

Receptors, Progesterone

Biomarkers, Tumor

Prognosis

Aged, 80 and over

Source

Open in PubMed Open full text

Identifiers

PMID: 39596311
DOI: 10.3390/ijms252212246
PMCID: PMC11594956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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