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PIK3Cδ expression by fibroblasts promotes triple-negative breast cancer progression

19 Mar 2020

Abstract excerpt

As there is growing evidence for the tumor microenvironment's role in tumorigenesis, we investigated the role of fibroblast-expressed kinases in triple-negative breast cancer (TNBC). Using a high-throughput kinome screen combined with 3D invasion assays, we identified fibroblast-expressed PIK3Cδ (f-PIK3Cδ) as a key regulator of cancer progression. Although PIK3Cδ was expressed in primary fibroblasts derived from...

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PMID: 32125284
DOI: 10.1172/jci128313

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