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Article

Spectrum of PIK3CA/AKT mutations across molecular subtypes of triple-negative breast cancer.

Breast cancer research and treatment - 1 Jun 2021

Kumar Sandeep, Bal Amanjit, Das Ashim, Loriya Ishita, Khare Siddhant, Bhattacharya Shalmoli, Singh Gurpreet

Abstract excerpt

PURPOSE: The heterogeneity of triple-negative breast cancer (TNBC) confers variable response to chemotherapy that results in poor outcome and relapse. Due to lack of targeted therapy, there is a need to provide molecular classification of TNBC and identify probable therapeutic targets. METHODS: We classified TNBC into surrogate molecular subtypes by immunohistochemistry and evaluated hotspot mutations (N = 80) in...

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PMID: 33954864
DOI: 10.1007/s10549-021-06242-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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