Genetic Analysis of Lung Cancer and the Germline Impact on Somatic Mutation Burden.

doi:10.1093/jnci/djac087

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Article

Genetic Analysis of Lung Cancer and the Germline Impact on Somatic Mutation Burden.

Journal of the National Cancer Institute - 8 Aug 2022

Gabriel Aurélie A G, Atkins Joshua R, Penha Ricardo C C, Smith-Byrne Karl, Gaborieau Valerie, Voegele Catherine, Abedi-Ardekani Behnoush, Milojevic Maja, Olaso Robert, Meyer Vincent, Boland Anne, Deleuze Jean François, Zaridze David, Mukeriya Anush, Swiatkowska Beata, Janout Vladimir, Schejbalová Miriam, Mates Dana, Stojšić Jelena, Ognjanovic Miodrag, Witte John S, Rashkin Sara R, Kachuri Linda, Hung Rayjean J, Kar Siddhartha, Brennan Paul, Sertier Anne-Sophie, Ferrari Anthony, Viari Alain, Johansson Mattias, Amos Christopher I, Foll Matthieu, McKay James D

Abstract excerpt

BACKGROUND: Germline genetic variation contributes to lung cancer (LC) susceptibility. Previous genome-wide association studies (GWAS) have implicated susceptibility loci involved in smoking behaviors and DNA repair genes, but further work is required to identify susceptibility variants. METHODS: To identify LC susceptibility loci, a family history-based genome-wide association by proxy (GWAx) of LC (48 843...

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PMID: 35511172
DOI: 10.1093/jnci/djac087
PMCID: PMC9360465

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