Global epistasis emerges from a generic model of a complex trait.

doi:10.7554/eLife.64740

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Article

Global epistasis emerges from a generic model of a complex trait.

eLife - 29 Mar 2021

Reddy Gautam, Desai Michael M

Abstract excerpt

Epistasis between mutations can make adaptation contingent on evolutionary history. Yet despite widespread 'microscopic' epistasis between the mutations involved, microbial evolution experiments show consistent patterns of fitness increase between replicate lines. Recent work shows that this consistency is driven in part by global patterns of diminishing-returns and increasing-costs epistasis, which make...

Topics

Epistasis, Genetic
Escherichia coli
Evolution, Molecular
Models, Genetic
Multifactorial Inheritance
Mutation

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Identifiers

PMID: 33779543
DOI: 10.7554/eLife.64740
PMCID: PMC8057814

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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