Article
Mutational robustness changes during long-term adaptation in laboratory budding yeast populations.
eLife - 26 Jul 2022
Johnson Milo S, Desai Michael M
Abstract excerpt
As an adapting population traverses the fitness landscape, its local neighborhood (i.e., the collection of fitness effects of single-step mutations) can change shape because of interactions with mutations acquired during evolution. These changes to the distribution of fitness effects can affect b...
Topics
- Adaptation, Physiological
- Epistasis, Genetic
- Evolution, Molecular
- Genetic Fitness
- Models, Genetic
- Mutation
- Saccharomyces cerevisiae
- Saccharomycetales