Article
Idiosyncratic epistasis leads to global fitness-correlated trends.
Science (New York, N.Y.) - 6 May 2022
Bakerlee Christopher W, Nguyen Ba Alex N, Shulgina Yekaterina, Rojas Echenique Jose I, Desai Michael M
Abstract excerpt
Epistasis can markedly affect evolutionary trajectories. In recent decades, protein-level fitness landscapes have revealed extensive idiosyncratic epistasis among specific mutations. By contrast, other work has found ubiquitous and apparently nonspecific patterns of global diminishing-returns and increasing-costs epistasis among mutations across the genome. Here, we used a hierarchical CRISPR gene drive system to...
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