Genotype-fitness mapping of adaptive mutants reveals shifting low-dimensional structure across divergent environments.

Abstract excerpt

A central goal in evolutionary biology is to predict the effect of a genetic mutation on fitness. This is a major challenge because it requires knowledge of both the phenotypic effects of a mutation and their importance in an arbitrary environment, which are high-dimensional quantities and difficult to guess a priori. Here, we address this problem by taking a top-down, data-driven approach to infer the mapping...

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