Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation.

Abstract excerpt

Building a genotype-phenotype-fitness map of adaptation is a central goal in evolutionary biology. It is difficult even when adaptive mutations are known because it is hard to enumerate which phenotypes make these mutations adaptive. We address this problem by first quantifying how the fitness of hundreds of adaptive yeast mutants responds to subtle environmental shifts. We then model the number of phenotypes...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adaptation, Physiological
• Share to Biological Evolution