Article
The environment affects epistatic interactions to alter the topology of an empirical fitness landscape.
PLoS genetics - 1 Apr 2013
Flynn Kenneth M, Cooper Tim F, Moore Francisco B-G, Cooper Vaughn S
Abstract excerpt
The fitness effect of mutations can be influenced by their interactions with the environment, other mutations, or both. Previously, we constructed 32 ( = 2⁵) genotypes that comprise all possible combinations of the first five beneficial mutations to fix in a laboratory-evolved population of Escherichia coli. We found that (i) all five mutations were beneficial for the background on which they occurred; (ii)...
Topics
- Adaptation, Physiological
- Epistasis, Genetic
- Escherichia coli
- Gene-Environment Interaction
- Genetic Fitness
- Genetic Pleiotropy
- Genotype
- Models, Genetic
- Mutation
- Selection, Genetic