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Article

MMTV RNA packaging requires an extended long-range interaction for productive Gag binding to packaging signals.

PLoS biology - 1 Oct 2024

Prabhu Suresha G, Pillai Vineeta N, Ali Lizna Mohamed, Vivet-Boudou Valérie, Chameettachal Akhil, Bernacchi Serena, Mustafa Farah, Marquet Roland, Rizvi Tahir A

Abstract excerpt

The packaging of genomic RNA (gRNA) into retroviral particles relies on the specific recognition by the Gag precursor of packaging signals (Psi), which maintain a complex secondary structure through long-range interactions (LRIs). However, it remains unclear whether the binding of Gag to Psi alone is enough to promote RNA packaging and what role LRIs play in this process. Using mouse mammary tumor virus (MMTV),...

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Identifiers

PMID: 39361708
DOI: 10.1371/journal.pbio.3002827
PMCID: PMC11449360

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